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Join Our Treatment Studies

Featured Research Study - Recruiting Now!

Psychotherapy study for mid-and late-life depression

Have you been feeling down or depressed? The University of Washington, Weill Cornell Medicine, and Talkspace are conducting a study to better understand the effectiveness of online counseling for depression. No need to schedule or travel to any sessions, as com-munication is through texting. Commit to 9 weeks of online therapy and answer simple questions about your mood during these 9 weeks and receive $15 for your participation. 

To participate, you must be: 

✔︎ 50 years or older 

✔︎ English speaking 

✔︎ Experiencing symptoms of depression or anxiety 

✔︎ Have a smartphone and be able to text 

Take advantage of this opportunity for high quality care and help. 

Find out if you’re eligible at: https://tsassessments.typeform.com/to/K3imD5 

Naltrexone Treatment for Prolonged Grief Disorder

Description:

This is a study to see how effective oral naltrexone is as treatment for prolonged grief disorder (PGD). Participants will take their assigned medication for 8 weeks, with monthly visits to assess symptom severity, social connectedness, and adverse reactions.

Primary Investigator:
Holly G Prigerson
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Social Reward and its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression

Description:

Abnormalities in the Positive Valence System (PVS) are associated with depressive symptoms and reduced behavioral activation in mid- and late-life. This study will investigate the engagement of the PVS during exposure to social rewards, part of a novel streamlined psychotherapy for mid- and late-life depression. Use of computational modeling will enable identification of neuroimaging and behavioral profiles associated with greater treatment response, and may guide future personalization of psychotherapy.

Primary Investigator:
Nili Solomonov, PhD
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Reward Processing in Aging and Depression (RAD)

Description:

This study will use task-based fMRI and computational modeling to examine how age and late-life depressive symptomatology influence neural network functions and resulting reward and salience processes. This is an observational study that aims to characterize abnormalities in the reward system and salience network at a single timepoint in older adults diagnosed with major depressive disorder and psychiatrically normal controls.

Eligible participants will first complete an assessment session, during which clinical and self- report scales will be administered. Within two business days of the assessment session, participants will complete an MRI scan. We will investigate the association between fMRI activation, behavioral performance, and assessment scores.

Primary Investigator:
Lindsay Victoria, PhD
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Hypertension, Brain Clearance, and Markers of Neurodegeneration

Description:

The purpose of this study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure. CSF cushions the brain from impact and carries waste products from the brain to the bloodstream. This process is known as clearance. 

Researchers have considered that impaired clearance of amyloid (a protein) from the aging brain causes buildup of amyloid in the brain and plays a role in increased risk for Alzheimer’s disease. It is also suspected that clearance may be related to the health of vessels carrying the blood throughout the brain. It is known that high blood pressure damages blood vessels and thus may impair clearance.  

In this project we will examine if having high blood pressure is related to impaired brain clearance and whether treating high blood pressure improves clearance and reduces buildup of Alzheimer’s disease-related proteins. This study will examine CSF clearance using positron emission tomography (PET) scanning, which creates images of structures in the body and their functioning. This study will also measure the amount of tau in the brain. Tau and amyloid are proteins that build up in the brains of people with Alzheimer’s disease. 

An investigational compound (tracer) called [18F]MK-6240 is injected into the blood prior to the scan in order to take images of the CSF clearance and measure tau protein in the brain. This tracer is considered investigational because it is not approved by the US Food and Drug Administration (FDA) for clinical use and is only being used for research purposes. 

In addition to the assessment of tau amount in the brain with PET study described above, the buildup of Alzheimer’s disease-related proteins will also be examined by directly measuring amyloid and tau in the cerebrospinal fluid. To accomplish this goal we will perform lumbar puncture, also known as a spinal tap. 

The procedures that each participant will partake in include medical and neurological examination, cognitive testing, blood draw and urinalysis, blood sample donation, electrocardiogram, blood pressure measurement and monitoring, lumbar puncture, MRI and PET scan. Reimbursement will be discussed at initial meeting.
Primary Investigator:
Lidia Glodzik, MD, PhD
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Trauma-focused Psychodynamic Therapy for Underserved LGBT Patients With Post-traumatic Stress Disorder

Description:

Despite high prevalence of PTSD among LGBT individuals, there are no data characterizing the disorder in this population, nor its treatment. This represents an important under-researched area in LGBT care and treatment. The purpose of this study is: (a) to preliminarily characterize PTSD within an LGBT sample; and (b) to test out the preliminary effects and acceptability of a novel PTSD psychotherapy, trauma-focused psychodynamic psychotherapy, in this group.

Participants identifying as LGBT and meeting DSM-5 criteria for PTSD per a structured, reliable clinical interview for PTSD will receive 20-24 sessions of twice-weekly trauma-focused psychodynamic psychotherapy (TFPP), an experimental intervention, at no cost. Participants will receive four detailed clinical research assessments, at baseline/study entry, Week 5 of treatment, treatment termination/end (Week 12), and 3-months after the end of treatment.

The psychotherapy and assessments in this study have been approved to be performed remotely using teletherapy platforms during the COVID-19 public health crisis.

TFPP is adapted from the only empirically supported, non-exposure focused psychodynamic therapy for panic disorder and anxiety disorders, panic-focused psychodynamic psychotherapy. TFPP aims to improve patients' ability to understand and manage strong, intense emotions that appear seemingly "out of the blue," which links to their tendency to reexperience traumatic events in the here-and-now. TFPP addresses the psychological meanings of symptoms and their relationship to traumatic events to help the patient understand underlying emotions triggering their symptoms and the ways in which trauma influences their current experiences. TFPP was developed for patients with complex PTSD, who often have multiple prior trauma exposures with no clear "index" trauma. Moreover, TFPP also explicitly considers opportunities for patients to explore the broader context of their symptoms and difficulties, including but not limited to LGBT identity or experiences of oppression.

Primary Investigator:
John Keefe, PhD
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COVID-19 Prevention Network (CoVPN) Screening Registry

Description:

The purpose of this study is to create a registry of volunteers interested in participating in COVID-19 vaccine research. This registry will only be used by researchers at Weill Cornell Medicine (WCM) to identify persons that could be eligible to participate in what we hope will be multiple clinical trials of various COVID-19 vaccines. By entering the registry, you may be able help us understand if certain vaccines can prevent infections with the virus that causes COVID-19.

We anticipate a tremendous amount of interest so we cannot promise to contact all who are interested. We ask that you please complete only one questionnaire per person.

Please understand that your participation in this screening registry is entirely voluntary and you can elect to withdraw from the registry at any time. You may not benefit from participating in this registry. This registry will remain open until the study team has finished recruiting volunteers into the last COVID-19 prevention study which potentially may occur several years from now.

You may be withdrawn from the registry by study staff you enroll in a COVID-19 prevention study, if you do not meet criteria for any of the related studies, or for administrative reasons. This can occur without your consent.

For those interested in joining the study, please visit our registry at: COVID-19 Prevention Network (CoVPN) Screening Registry.

Primary Investigator:
Kristen Marks, MD
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A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19

Description:

Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases, such as Middle East respiratory syndrome and SARS-CoV. Coronaviruses are zoonotic, meaning they are transmitted between animals and people.

There is currently no vaccine that has been shown to be effective against SARS-CoV-2. Therefore, there is an urgent public health need for rapid development of novel interventions to prevent the spread of this disease. This study is testing the mRNA-1273 study vaccine at a dose of 100 micrograms (µg). The mRNA-1273 study vaccine is intended to boost the immune system to produce enough antibodies against SARS-CoV-2; so, in case of an exposure, the virus does not cause illness.

The main purpose of this study is to understand if mRNA-1273 can prevent COVID-19 and to understand the safety of the mRNA-1273 study vaccine. 

The study length is 25 months and includes approximately 6 visits to the clinic and 25 phone calls. If you chose to participate in this study, you will receive 2 injections of study vaccine or placebo given about 1 month apart. All subjects will be randomly assigned to receive two doses of 100 µg [microgram] of an experimental study vaccine called “mRNA-1273” or a placebo (a saline injection that contains no active ingredients). Each subject will receive an injection of mRNA-1273 100 µg [microgram] or placebo at Visit 1 (Day 1) and at Visit 2 (Day 29). This random assignment (like flipping a coin) will be a 1:1 ratio.

For those interested in joining the study, please visit our registry at: COVID-19 Prevention Network (CoVPN) Screening Registry.

Primary Investigator:
Kristen Marks, MD
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Perimenopause and Brain Aging in Alzheimer's Disease

Description:

The purpose of this study is to better identify and predict individuals at risk for Alzheimer's disease (AD) who are most likely to benefit from personalized, evidence-based interventions. Studies have shown that endocrine aging (menopause, perimenopause) increases Alzheimer’s disease risk specifically in women. Our goal is to unravel the biological mechanisms behind the increased risk by analyzing how various measures of brain function, biochemistry, laboratory values, and other risk factors may influence Alzheimer’s risk as women age. The ultimate goal of this research is to help characterize the optimal window of opportunity for therapeutic intervention in women at risk for Alzheimer’s.

Primary Investigator:
Lisa Mosconi, PhD
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Brain Estrogen Imaging in Women at Risk for Alzheimer’s

Description:

The mission for this project is to investigate whether the perimenopause to menopause transition, a neuroendocrine transition state specific to the female, drives Alzheimer’s disease (AD) endophenotype in women, thereby playing a determinant role in the well-established increased prevalence of AD in women. As late-onset AD accounts for the greatest incidence and prevalence of the disease, determining sex-specific molecular mechanisms relevant to AD onset and progression has the potential for greatest impact. Further, examination of early stage transitions of risk has the greatest potential for identification of therapeutic targets to change the trajectory of the disease to prevent, delay and potentially reverse course of developing AD.

Translational studies point to the decline in brain 17beta-estradiol as a female-specific trigger for AD. The goal of this study is to examine 16α-[18F]fluoro-17β-estradiol (FES), a selective estrogen receptor (ER) ligand with binding affinity equal to 80% of that of estradiol, for assessment of brain ER activity in humans. Our goals are to leverage our active grants to perform FES-PET in 50 clinically and cognitively normal female participants, aged 40-65 years at different endocrine transition stages. Brain ER status in these groups will be compared to brain biomarkers of AD, e.g. Aβ deposition of PiB-PET, glucose metabolism on FDG-PET, and atrophy on MRI, as well as cognitive performance.

Outcomes of our analyses will elucidate molecular mechanisms that emerge in midlife and that increase risk of developing AD later in life. Collectively, these data will provide therapeutic targets for sex-based precision medicine interventions during the prodromal phase of late-onset AD, when the potential to reverse, prevent and delay AD progression is greatest.

Primary Investigator:
Lisa Mosconi, PhD
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COVID-19 Reproductive (Repro) Health Survey

Description:

This study seeks to understand how the COVID-19 pandemic is affecting reproductive choices and access to reproductive health care for women ages 18 to 45 who are living in the United States (US).

Please consider taking this brief, anonymous COVID-19 Repro Survey to share your experiences. Your participation will help physicians to learn how best to provide reproductive care to women in times of widespread crisis.

Your answers will be anonymous. No IP addresses or any other information that could be used to identify you will be collected.

This survey was conceived and developed by Susan Loeb-Zeitlin, MD and Margaret Polaneczky, MD at Weill Cornell Medicine. It is not intended to provide medical care or advice. If you have concerns about your personal health, please contact your health care provider.

Thank you for taking the time to add your voice to this research initiative.

Primary Investigator:
Margaret M Polaneczky, MD
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Examining Approach Motivation in Depressed Middle-Aged and Older Adults

Description:

This behavioral study will examine how different self-report and clinical rating scales correlate with motivation processes in middle-aged and older adults with depression. The goal is to identify simple measures for characterizing abnormalities in motivation in depressed patients that can be used in the community. Administration of these measures at the outset and during treatment will allow community clinicians to optimize the selection and timing of behavioral interventions. 

Primary Investigator:
Faith Gunning, PhD
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Mobile Cognitive Behavior Therapy Targeting Anxiety Disorders

Description:

This study is testing a new mobile app meant for treating anxiety in young adults.

This study involves downloading and using an iPhone app and receiving text messages. You’d be asked to use the app at least twice a week for 20-30 minutes each time. This study involves weekly assessments of your mood and anxiety while you use the app, and one follow-up assessment six weeks later. Participants are compensated $50 each for the baseline, midpoint, endpoint, and follow-up assessments, for a total of $200. There is also an option to complete two MRI scans at Weill Cornell Medicine, before and after using the app program, for an additional $200.

The app is based on cognitive behavioral therapy, an evidence-based treatment for anxiety. Interacting with the app involves watching videos about anxiety, practicing exercises to target challenging thoughts and behaviors, and using relaxation and coping techniques.

Primary Investigator:
Faith Gunning, PhD
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Data-Driven Multidimensional Modeling of Nonverbal Communication in Typical and Atypical Development

Description:

This study aims to develop and validate data-driven computational models of the temporal coordination and production of NVC behaviors during dyadic social interactions in TD, ASD, and DD children. We also aim to identify the fine-grained properties of coordination of motor movement and NVC captured by computational models that are most predictive of diagnostic group and one-year language outcomes. Finally, we will explore novel NVC coordination patterns via bottom-up clustering of motor 

Primary Investigator:
So Hyun Kim, PhD
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Brain and Behavioral Changes Over Time in Young Children with Autism

Description:

This study has the goal of furthering our understanding of the longitudinal course of autism spectrum disorder (ASD). Specifically, we propose a longitudinal study of young children with ASD (2-3 years) to identify the neurobiological underpinnings of early developmental changes in restricted repetitive behavior/interests (RRB), one of the most clinically impairing aspects of ASD - and their predictive contribution to later function. 

Primary Investigator:
So Hyun Kim, PhD
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Relief: A Behavioral Intervention for Depression and Chronic Pain in Primary Care

Description:

This 9-session behavioral intervention was developed to address the need of primary care interventions for people experiencing chronic pain and depression, which co-exist in late and mid-life, contributing to increased disability, high health care costs, psychiatric comorbidities, and suicide. Participants will have clinically significant depression and suffer from chronic pain and receive either 9 weeks of RELIEF therapy or Usual Care. Research assessments will be conducted at entry, and at 6, 9, and 12 weeks. 

Primary Investigator:
Dimitris N Kiosses, PhD
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Enhancing Your Wellness and Social Engagement

Description:

The purpose of the study is to help older adults engage in physical exercise and also to help social engagement (opportunities to meet new people). We want to determine whether the Fittle Silver application (app) is effective in engaging older adults in physical activity and increasing social support. The Fittle Silver app is placed on a computer tablet. You are being asked to take part in this study because you are an adult over the age of 60, and are not currently engaged in a physical exercise program or in regular physical exercise activities. 

Primary Investigator:
Sara Czaja, PhD
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Understanding Prediction Error and Affective Salience Abnormalities to Guide the Selection of Reward Exposure Activities

Description:

This pilot study examines the interaction of reward and salience abnormalities in depression with the goal to inform a simple-to-administer, structured assessment that will sharpen the targeting of behavioral interventions. 

This pilot studies the interplay of reward expectancy and salience functions in mid- and late-life depression. Focusing on three levels of analysis (neural circuitry, performance of PVS-related tasks, self-report/clinical observations) will offer a view of the relationship of neural activation with clinical symptoms. 

Primary Investigator:
Lindsay Victoria, PhD
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Validating a Measure of Social Communication Change in ASD

Description:

This study has the goal of furthering our understanding of measuring changes in the presentation of Autism Spectrum Disorder (ASD) symptoms over the lifetime. Specifically, we will measure subtle changes in core symptoms of ASD, including social skills and repetitive and restricted behaviors/interests through the Brief Observation of Social Communication Change (BOSCC). While other diagnostic tests (e.g. ADOS-2, ADI-R) measure these clinical symptoms, they are less sensitive to subtle changes across time that may be a result of intervention, therapy, or other developmental changes. The study will collect short video observations across age (6 months through adults, lifespan), setting (i.e. clinic, home), activity, and social partner (i.e. clinician, parent), in people with ASD, in addition to a typically developing sample at two time points (3-6 months apart, depending on the length of treatment).

Primary Investigator:
So Hyun Kim, PhD
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Assessment of Physiological Reactions Associated with Post-traumatic Stress Disorder Due to Military Sexual Trauma in Female Service Members

Description:

The purpose of this study is to evaluate physical reactions associated with PTSD that develops due to the experience of military sexual trauma.

Primary Investigator:
Melissa Peskin, PhD
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Problem Adaptation Therapy for Mild Cognitive Impairment and Depression

Description:

This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.

Primary Investigator:
Dimitris N Kiosses, PhD
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Using Virtual Reality in Exposure-Based Treatment for Social Anxiety in Youth

Description:

Anxiety disorders are the most common mental health diagnosis in the US and are associated with avoidance that causes functional impairments and decreases quality of life. Social anxiety disorder is among the most prevalent anxiety disorders, with most common age of onset being in adolescence. The frontline treatment for social anxiety disorder is cognitive behavioral therapy with exposure. However, a significant number of adolescent patients do not get better after completing cognitive behavioral therapy or experience relapse. Providing realistic learning contexts for exposure could be the key to enhancing treatment effects in adolescents. This is often challenging for a variety of reasons, including difficulty realistically mimicking anxiety-provoking social situations due to limited resources, clinician training, time, or motivation. Virtual reality environments could provide contextual exposures for social anxiety. 

The aims of this study are threefold: to assess feasibility of using virtual reality in treatment of social anxiety in youth, to examine whether virtual reality invokes arousal similar to anxiety and test the physiological assessment protocol, and to evaluate whether exposure using virtual reality environments reduces symptoms of social anxiety and related functional impairment. 

Primary Investigator:
Shannon M. Bennett, PhD
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Imaging of Resting State Functional Connectivity Following Transcranial Magnetic Stimulation

Description:

In our previous work, we have developed bio-markers from brain images of transcranial magnetic stimulation (TMS) treatment for depression. 

The goal of the current study is to build on this past work by looking at the immediate neural effects of a single session of several forms of TMS, previously established to be effective and safe. 

The findings of this study will help figure out the best TMS targets and forms of treatment in future intervention studies. Data from the current pilot trial will also inform future efforts to effectively match a TMS treatment method to each individual, based on this individual's brain patterns. 

Primary Investigator:
Marc Dubin, MD, PhD
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A Comprehensive Psychological Intervention to Improve Community and Vocational Reintegration Following Burn Injury and Other Trauma

Description:

The purpose of this study is to treat symptoms of posttraumatic stress disorder (PTSD) resulting from burn trauma using traditional treatment. 

The burn intervention study offers 14 sessions of free individual treatment for burn survivors with posttraumatic stress disorder. The treatment protocol focuses on reduction of the symptoms of PTSD, while simultaneously introducing skills to address the numerous sequelae of burn injury including feelings of depression, coping with scarring and/or disfigurement, reintegrating back into work, community, and social circles, and improving general functioning and quality of life. 

Primary Investigator:
JoAnn Difede, MD
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Virtual Reality for Pain Management in Burn Patients

Description:

We are conducting a randomized proof-of-concept study to assess the efficacy of virtual reality (VR) vs standard of care in 50 adult patients in the NewYork-Presbyterian Burn Unit. The participants who are randomized to receive the virtual reality intervention will also receive opioids, which is the standard of care and is known to be effective.

Participants will be randomly assigned to two groups. The first group will receive VR during their procedure in addition to the standard-of-care. The other group will receive standard of care during the wound dressing change procedure (and no VR). The reported levels of pain and the total amount of narcotic and analgesics from admission through discharge from the hospital will be recorded and analyzed as a secondary outcome: whether the VR condition impacts total received dose in the two days post-procedure and through hospital stay. 

Primary Investigator:
JoAnn Difede, MD
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D-Cycloserine Enhanced Imaginal Exposure Therapy for Post-Traumatic Stress Disorder (PTSD)

Description:

The purpose of this study is to treat symptoms of post-traumatic stress disorder (PTSD) resulting from various traumas using traditional treatment combined with the use of D-Cycloserine (DCS). 

Treatment is offered on an individual basis for 12-14 weekly sessions lasting approximately 75-90 minutes each. This cognitive-behavioral treatment aims to introduce skills and techniques that will reduce symptoms and improve quality of life. One essential component of the treatment includes describing one's traumatic experience. Participants will be randomly assigned to take either a low dose of D-Cycloserine (DCS; a broad-spectrum antibiotic) or a placebo pill prior to their weekly session to examine the effects of DCS on treatment. Thus treatment incorporates traditional techniques that have been shown to be effective in treating PTSD, with cutting edge pharmacology to enhance the treatment. Treating clinicians are all highly experienced in working with PTSD, civilians and disaster workers. 

Primary Investigator:
JoAnn Difede, MD
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A Non-Inferiority Randomized Controlled Clinical Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Consequent to Military Sexual Trauma (MST) in Male and Female Military Personnel and Veterans

Description:

The purpose of this study is to compare two kinds of therapy for post-traumatic stress disorder (PTSD): exposure therapy (ET) and interpersonal psychotherapy (IPT). The results of this study will allow us to see if IPT and ET are equally effective in treating PTSD due to military sexual trauma, with the long-term goal of making PTSD treatment effective for as many people as possible. 

Primary Investigator:
JoAnn Difede, MD
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A POC Clinical Trial for a First-in-Class Vasopressin 1a Receptor Antagonist

Description:

We are seeking participants for a clinical trial which will test an experimental drug for the treatment of post-traumatic stress disorder (PTSD). 

Following the initial screening phase, you will receive the medication treatment for 8 weeks and the placebo for 8 weeks. The study will last a total of 18 weeks, and you will be assessed at baseline and then every 2 weeks until the end of the study. You will be compensated for all completed assessments (up to a total of $400). 

Primary Investigator:
JoAnn Difede, MD
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Positive Valence System Function and Reward Exposure Therapy for Late-Life Depression

Description:

The goal of this study is to learn about changes in the brain that occur during Engage, a psychotherapy for depression in older adults, and how they may differ from changes that occur during supportive therapy. Older adults with depression will receive 9 weeks of either Engage or supportive therapy and will complete research assessments before the therapy begins and at weeks 3, 6, and 9 of treatment. Research assessments will include questionnaires, computer tasks, and recordings of electrical brain activity (also called electroencephalography or EEG). 

Primary Investigator:
Jennifer Bress, PhD
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Brain Function, Emotions, and Behavior in Healthy Older Adults

Description:

The purpose of this study is to compare thinking, emotions, and brain function in older adults without a history of psychiatric illness to older adults who are receiving treatment for depression in our other studies. This research is being done to help develop, understand, and improve treatments for depression in older adults. 

Research assessments will be conducted at three time points – baseline, week 6, and week 9 – and will include measuring brain activity, computer tasks, and questionnaires about mood and thoughts. Participants are compensated for each visit. 

Primary Investigator:
Jennifer Bress, PhD
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Efficacy of Biomarker-Guided rTMS for Treatment Resistant Depression

Description:

Depression is the second leading cause of disability worldwide, due partly to the fact that existing antidepressants are not effective for all patients and it is often challenging to match individual patients to the treatments that are most likely to help them. This study will test a new strategy for using fMRI brain scans to predict antidepressant response and assist clinicians in choosing antidepressant treatments. Transcranial magnetic stimulation targeting one of two depression-related brain areas is most likely to benefit an individual patient. 

Primary Investigator:
Conor Liston, MD, PhD
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Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

Description:

The purpose of this clinical trial is to determine whether screening for breast cancer with tomosynthesis mammography is superior to digital mammography. To determine that, we are studying whether women who are screened for breast cancer with tomosynthesis mammography have fewer advanced breast cancers compared with the number of such cancers found when women are screened for breast cancer with digital mammography. This study will also compare whether there is a difference in the number of additional tests recommended after tomosynthesis mammography and digital mammography. 

Primary Investigator:
Michele B Drotman, MD
Contact Name:
Eileen Chang
Contact Email:
eic2002@med.cornell.edu
Contact Phone:
212-746-6248

Genetic Markers of Longitudinal Course of PTSD Symptoms Following Traumatic Events

Description:

Weill Cornell Medical College researchers seek participants who experienced a traumatic event for a one year post traumatic stress disorder (PTSD) study. Participants will be assessed for PTSD and related symptomatology and followed up for 1 year. Participants will also contribute saliva sample for genetic biomarkers analysis.

This study aims to test genetic predictors of PTSD following trauma and to understand the longitudinal course of PTSD in trauma survivors, including psychiatric symptoms, impairment, and reaction to reintegration to daily life. All assessments are free of cost and confidential.

Primary Investigator:
JoAnn Difede, MD
Contact Name:
Annell Ovailes
Contact Email:
ano2015@med.cornell.edu
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Pancreatic Cancer Early Detection Using a Urine Test for Mutated K-ras DNA

Description:

This clinical trial is for men and women diagnosed with metastatic pancreatic cancer as well as healthy individuals. The purpose of this research study is to develop a safe method for finding pancreatic cancer using a new technology of finding and detecting pancreatic cancer DNA markers in adult urine. In order to continue to improve the way pancreatic cancer is found in patients, the researchers must be able to obtain urine samples from patients who may or may not have pancreatic cancer and test their urine for DNA fragments that contains pancreatic DNA markers. Eligible patients will have urine and blood collected for correlative reference. 

Primary Investigator:
Allyson J Ocean, MD
Contact Name:
Alice F. Mercado
Contact Email:
alm2051@med.cornell.edu
Contact Phone:
646.962.3080

A Computerized Intervention Targeting Cognitive Control Network Deficits in Depression

Description:

The Weill Cornell Institite of Geriatric Pyschiatry is conducting a research study of depression in adults ages 45-75 years old using a cognitive training delivered on iPads. This study is voluntary and will not influence your regular medical care. iPads are provided on loan.

Eligible individuals who agree to participate will:

  • Take part in an initial screening interview
  • Receive 4 weeks of Game-Play sessions designed to improve cognitive abilities
  • Take part in clinical interviews before starting Game-Play, immediately following 4 weeks of Game-Play, and 4 weeks following the end of Game-Play
  • Receive two MRI scans (one before starting Game-Play, and one immediately following 4 weeks of Game-Play) 

Participants will not be charged for any services. Participants will be compensated up to $575 by the end of the study. 

All information is confidential. To learn more, please call 212-746-3749.

Primary Investigator:
Faith Gunning, PhD
Contact Name:
Maria Coluccio
Contact Email:
mac2118@med.cornell.edu
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Evaluation of an anxiety intervention for older adults with cancer and informal caregivers of older adults with cancer

Description:

This study is for men and women who are 65 years or older with cancer and informal caregivers of people 65 years or older with cancer. Informal caregivers are family and/or friends of cancer patients who provide physical, emotional, and/or practical support to the patient and are not paid for providing this care.

To participate in this study, patients and/or caregivers must also be experiencing elevated anxiety levels. This study is being conducted because approximately 60% of new cancer diagnoses are in patents 65 years or older, anxiety is common in these patients and their caregivers, and psychological interventions specifically for older adults with cancer and their informal caregivers have not been developed and evaluated. The purpose of this study is to determine whether the intervention has a clinically significant effect on patients' and caregivers' anxiety.

Primary Investigator:
Holly G Prigerson
Contact Name:
Lauren Meador
Contact Email:
lam2030@med.cornell.edu
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Can Cognitive Training Decrease Reactive Aggression? The Role of Improved Emotion Regulation, Emotion Awareness, and Impulse Control

Description:

The purpose of this study is to find out if participating in activities that train cognitive skills can improve your ability to manage your emotions. 

This research study is being done because severe mental illnesses can contribute to problems managing emotions during stressful situations. These difficulties with managing emotions result from difficulties with cognition. Cognition refers to your thinking skills—your ability to remember, focus, think quickly, reason, solve problems, and recognize other people’s emotions. We are interested in finding out if by training your thinking skills; we can improve your ability to manage emotions and aggression. 

We have developed a program that includes several activities that help people think better faster, and more efficiently. The purpose of the study is to see if the treatment program that includes computer training activities can help improve your thinking skills and your ability to manage your emotions.

Primary Investigator:
Anthony O. Ahmed
Contact Name:
Anthony O. Ahmed
Contact Email:
aoa9001@med.cornell.edu
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Collection of Airway, Blood, and/or Urine Specimens from Subjects for Research Studies

Description:

Currently recruiting: People with lung disease and Healthy Volunteers

This clinical trial is designed to collect samples from healthy individuals and individuals with lung disorders to compare specific factors in each. Blood, urine, and airway cells are collected to learn more about the specific causes of lung disease, how lung disease manifests, progresses, and how it can be treated.  Normal healthy volunteers will be used to establish what is considered a normal range for various parameters. This trial is also used to store specimens for future genetic studies.

The purpose of this study is to collect samples from healthy individuals and individuals with lung disease to help in the understanding of the origins and mechanisms of various lung disorders. The main idea is to see if there are changes within the genetic expression of airway cells in patients with lung disorders before there are actual physical changes within the lungs. 

This is a collection study, and no study medication will be given to treat airway disorders. This study is comprised of three main parts. The first is a telephone pre-screening interview. The interview will take about 15 minutes, where questions will be asked about the subject’s background. This will determine if a subject is eligible for the second portion of the study, called the initial screening visit. This will take 4-5 hours and may include blood and urine tests, a physical exam, a chest x-ray, an EKG, and a breathing test. Compensation for completion of the initial screening visit will be $50. If a subject is considered eligible, they will undergo the third part of the study, called the bronchoscopy.  A bronchoscopy is a routine procedure doctors use to look at the inside airways of the lungs. A very thin and flexible tube is inserted down the throat into the lungs for sample collection. The bronchoscopy will take about 2 hours. 

Potential subject compensation as follows:
Full screening: $50
Partial screening: $25
Bronchoscopy: $200
Patient referral (if referred patient completed entire study): $25/patient

Key eligibility:

  • This study is open to men and women ages 18 and older and who are able to provide consent
  • Volunteer subjects with lung disease, the lung disease must be proven with any of the following: symptoms, chest X-rays, pulmonary function tests, lung biopsy, family history, and or/diseases or organs with known association with lung disease
  • Healthy volunteer subjects, must be deemed in overall good health without a history of chronic lung disease or specific drug use
  • Individuals with certain allergies will not be accepted for their safety
  • Women who are pregnant or nursing will not be accepted for their safety
  • Detailed eligibility reviewed when you contact the study team
Primary Investigator:
Clotell Hanks, MD
Contact Name:
Grace W. Mammen
Contact Email:
gwm2004@med.cornell.edu
Contact Phone:
(646) 962-4537

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Antidepressant Medication Study for Older Adults with Depression

Persistent Sadness…

            Loss of Interests and Pleasure…

                        Low Energy or Sleeplessness…

                                    Are Just Some Signs of Depression

The Weill Cornell Institute of Geriatric Psychiatry is conducting a research study of depression in adults 60 and older using an FDA-approved antidepressant medication.

Eligible individuals who agree to participate will. . .

  • receive free study medication and physician visits,
  • take part in clinical interviews,
  • receive two MRI scans, and
  • be compensated up to $340 for completing the entire three month study.

All information is confidential.

To learn more, please call: (800) NYP-1902 or 914-997-4331

The Weill Cornell Institute of Geriatric Psychiatry
NewYork-Presbyterian Westchester Behavioral Health Center
21 Bloomingdale Road
White Plains, NY 10605

Protocol # 1205012392

The PATH-MCI Study for Older Adults with Depression and Memory Problems

The Weill Cornell Institute of Geriatric Psychiatry is currently conducting the PATH-MCI Study, a six month research study supported by the National Institute on Aging investigating two talk therapies for treating depression in older adults with memory or other thinking problems.

  • Are you between the ages of 60 and 85 years?
  • Do you feel fatigue, loss of energy, sad, discouraged, or have you lost interest in doing things?
  • Do you experience memory or other thinking difficulties?
  • Are you currently having difficulty doing activities that you were previously doing?
  • Do you feel you could use new coping strategies to help with your problems?

All study participants will receive talking therapy in our office in White Plain or Manhattan:         

  • A social worker will provide 15 psychotherapy sessions: 12 weekly sessions in the first 3 months and 3 monthly booster sessions at 4th, 5th and 6th month. 
  • The social worker will help you address the challenges or difficulties you are currently facing.
  • Each session lasts approximately one hour.
  • Study participants will be compensated for each research interview.

The study is currently recruiting in Manhattan, the Bronx, and Westchester County.

For more information about the PATH study, please call: Joanna Pantelides, (914) 682-9100 ext. 2903

The Weill Cornell Institute of Geriatric Psychiatry
New York-Presbyterian/Weill Cornell Medical Center
425 East 61st Street
New York, NY  10021

&

NewYork-Presbyterian Westchester Behavioral Health Center
21 Bloomingdale Road
White Plains, NY  10605 

IRB Protocol #1603017114

 

Study for Negative Thoughts in Middle-Aged and Older Adults

The Weill Cornell Institute of Geriatric Psychiatry is currently conducting a six month research study investigating different talking therapies for treating depression in older adults with negative thoughts about life, and difficulties in planning and organizing.

  • Are you 50 or older?
  • Do you feel fatigue, loss of energy, sad, discouraged, or have you lost interest in doing things?
  • Do you have difficulties in dealing with life stressors or in enjoying your everyday life?
  • Are you currently having difficulty doing activities that you were previously doing?

 All study participants will receive talking therapy in our office in White Plain or Manhattan:

  • A therapist will see you once a week for 12 weeks to help improve your negative thoughts, functioning and mood.
  • The therapist will help you address the challenges or difficulties you are currently facing.
  • Each session lasts about one hour. 
  • Study participants will also be compensated for each research interview.

The study is currently recruiting in Manhattan,  Bronx, Queens, and Westchester Counties.

For more information about the PATH-SP study, please call: Elizabeth Arslanoglou, (914) 682-9100 ext. 2491

The Weill Cornell Institute of Geriatric Psychiatry
NewYork-Presbyterian/Weill Cornell Medical Center
425 East 61st Street
New York, NY  10021

&

NewYork-Presbyterian Westchester Behavioral Health Center
21 Bloomingdale Road
White Plains, NY  10605
IRB Protocol #1402014762

  

The PATH for Pain Study for Older Adults with Chronic Pain and Negative Emotions

The Irving Sherwood Wright Center on Aging is currently conducting the PATH for Pain Study, a six-month research study supported by Pfizer, investigating if a specialized program involving talk therapy is effective in alleviating depression and improving pain and physical functioning in older adults who suffer with chronic pain.

  • Are you 60-89 years old and receive healthcare at the Wright Center on Aging?
  • Do you want to better manage your chronic pain and improve your mood?

All study participants meet with a researcher 4 times over a period of about 24 weeks to complete questionnaires and paper and pencil tasks evaluating your pain, mood, and thinking abilities.

  • Study participants will be compensated $20 for each of the 4 research interviews

Some study participants will receive a non-drug intervention (talk therapy), which will take place at the Irving Sherwood Wright Center on Aging. If selected for talk therapy:  

  • You will meet with a social worker once a week for 8 weeks to discuss ways to improve your functioning and your mood.
  • You may choose to have a study partner (family member, companion, home health aide) to participate in the study with you. The therapist will work with you and your study partner to address the challenges or difficulties you are currently facing.
  • Each therapy session lasts about one hour. 

This study is currently recruiting; for more information about the PATH for Pain study, please call:

Emily Petti, 212-746-7317Research Assistant, Division of Geriatrics and Palliative Medicine, Weill Cornell Medicine

 IRB Protocol #1509016564

 

 

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